Use generic cytotec during pregnancy and lactation 

The drug can be used by pregnant for her termination, otherwise it is absolutely contraindicated in pregnancy. In establishing a pregnancy in patients taking misoprostol, therapy with this drug should be discontinued. Need to inform patients about the potential dangers of misoprostol (teratogenic).
Breastfeeding should be discontinued for 7 days of mifepristone in the method of medical abortion (up to 5 days of administration of misoprostol).


Dosing and Administration
For pregnancy termination with mifepristone, the drug should be used in facilities that are appropriately trained medical personnel.
Inside, 36-48 hours after ingestion of 600 mg (3 tablets) of mifepristone prescribe 400 mcg (2 tablets) of misoprostol.

Side effect
When applied in early pregnancy is possible nausea, vomiting, dizziness, lethargy, pain in lower abdomen. Marked by an extremely rare cases of blood flow to the face, fever, itching and allergic reactions.

Overdose
The toxicity of misoprostol in humans was not detected. Clinical signs that may indicate excess dosages are drowsiness, tremor, muscle cramps, abdominal pain, fever, palpitation, hypotension, or bradycardia. USA and Canada.

Interaction with other drugs
Admission for a long time of rifampicin, isoniazid, anticonvulsants, antidepressants, cimetidine, aspirin, indomethacin, and barbiturates, smoking over 10 cigarettes a day, misoprostol stimulates the metabolism, reducing its level in serum.
Within 1 week after misoprostol should refuse to receive aspirin and other nonsteroidal anti-inflammatory drugs.

Cautions

   1. When applying for termination of early pregnancy, misoprostol should be used only in combination with mifepristone.
   2. In conjunction with mifepristone, misoprostol should be used only as intended and under the supervision of a physician and only in specialized medical institutions, the capacity to provide emergency obstetric and surgical transfusion support.
   3. Before the appointment of misoprostol patient must be informed in detail about the effects and possible side effects of the drug. Patient should be observed in a treatment facility for 4-6 hours before dosing. During and after treatment the patient should be provided timely medical assistance in case of massive bleeding or development of other pathologies.
   4. After taking the drug in patients, usually occurs some vaginal bleeding, the proportion of women is very long. At a very early pregnancy is possible miscarriage after mifepristone, but in this case also requires taking pills of misoprostol to optimize the results of drug exposure. After administration of misoprostol in approximately 80% of the miscarriage of women occurs within 6 hours and about 10% of women - within 1 week.
   5. Patients should undergo re-examination in the same hospital 8-15 days after ingestion. In case of necessity must be held ultrasound or determining the level of human chorionic gonadotropin in blood serum. In cases of suspected incomplete abortion or continuation of the pregnancy must be timely to conduct a comprehensive medical examination.
   6. Of incomplete abortion or ongoing pregnancy, estimated at 10-14 days of mifepristone, be sure to spend vakuumaspiratsiyu with subsequent histological examination of aspirate as possible formation of congenital malformations in the fetus.